most significant

ADJECTIVE

telling, meaningful

Synonyms

STRONGEST

compelling important momentous powerful serious symbolic

WEAK

cogent convincing denoting eloquent expressing expressive facund forceful heavy indicative knowing meaning pregnant representative rich sententious sound suggestive valid weighty

Antonyms

STRONGEST

insignificant trivial unimportant

WEAK

meaningless minor

ADJECTIVE

important, critical

Synonyms

STRONGEST

big consequential considerable meaningful momentous notable noteworthy serious substantial vital

WEAK

carrying a lot of weight heavy material weighty

Antonyms

STRONGEST

dull inconsequential insignificant little minor ordinary small trivial unimportant unnoticeable

WEAK

meaningless

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

"One of the most significant findings is that we have identified a molecule capable of restoring microglia's protective function," explains Sánchez Mut.

From Science Daily • Jun. 19, 2026

Perhaps the most significant opposition came from groups concerned about cultural and architectural sites along the transmission path.

From Los Angeles Times • Jun. 18, 2026

The most significant investigation was already underway, spearheaded by the Church Commissioners, the body responsible for managing the Church's multi-billion-pound investment fund.

From BBC • Jun. 18, 2026

"The pioneering spirit of generations of our people has forged that path ever since, and today is the most significant step in that mission in our 105-year history."

From Barron's • Jun. 17, 2026

In such a lonely void you can begin to understand how even the most significant objects–Pluto’s moon, for example–have escaped attention.

From "A Short History of Nearly Everything" by Bill Bryson